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Acceptance criteria for microbiological quality of non-sterile dosage forms Route of administration TAMC ( CFUg or CFUmL) TYMC ( CFUg or CFUmL) Specified micro-organisms Non-aqueous preparations for oral use 103 102 Absence of Escherichia coli (1 g or 1 mL) Aqueous preparations for oral use 102 101 Absence of Escherichia coli (1 g or 1 mL) Rectal use 103 102 - Oromucosal use Gingival use Cutaneous use Nasal use Auricular use 102 101 Absence of Staphylococcus aureus (1 g or 1 mL) Absence of Pseudomonas aeruginosa (1 g or 1 mL) Vaginal use 102 101 Absence of Pseudomonas aeruginosa (1 g or 1 mL) Absence of Staphylococcus aureus (1 g or 1 mL) Absence of Candida albicans (1 g or 1 mL) Transdermal patches (limits for one patch including adhesive layer and backing) 102 101 Absence of Staphylococcus aureus (1 patch) Absence of Pseudomonas aeruginosa (1 patch) Inhalation use (special requirements apply to liquid preparations for nebulisation) 102 101 Absence of Staphylococcus aureus (1 g or 1 mL) Absence of Pseudomonas aeruginosa (1 g or 1 mL) Absence of bile-tolerant gram-negative bacteria (1 g or 1 mL) Special Ph.
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